What makes tumours tick? Genomics pave the way for tailored treatments

Advances in genetic testing are enabling healthcare professionals to personalise treatments for diseases and conditions including cancer, diabetes and HIV

It’s remarkable how genomics is being used in NHS healthcare, particularly in cancer, where tests now look at the DNA of actual tumours rather than patients. As I have covered previously for ComputerWeekly.com, lung cancer is being targeted through the National Lung Matrix Study. It’s now the case that 15-20% of lung cancer patients can receive targeted treatment based on genomics.

Gary Middleton, professor of medical oncology at the University of Birmingham and chief investigator of the National Lung Matrix Study, put it this way in my new article on this for Guardian Healthcare Professionals Network:

Lung cancer used to be a very simple disease. There were very few treatments and patients did very poorly. It’s really quite complicated now. Keeping on top of the new drugs and the new indications is difficult.

The NHS is expanding infrastructure around genomics, including training and labs. Genomics has huge potential, although as Prof Middleton says it often makes healthcare more complicated by providing multiple treatment pathways for a single condition. This means saving more lives – but it is one of the many factors making healthcare more expensive.

Powered by Guardian.co.ukThis article titled “What makes tumours tick? Genomics pave the way for tailored treatments” was written by SA Mathieson, for theguardian.com on Tuesday 10th May 2016 10.19 UTC

Breakthroughs in genomic medicine are helping researchers to devise a new generation of personalised treatments for a range of diseases and conditions, including cancer, diabetes and HIV.

The cost of sequencing a human genome has fallen from m (£66m) in 2001 to just ,345 (£870), according to the US National Human Genome Research Institute. This is enabling professionals to tailor treatments based on the results of genetic tests.

Cancer, caused by mutations in the genes of human cells, is well-suited to genomic medicine. Cancer Research UK is funding the National Lung Matrix Study, also supported by the Experimental Cancer Medicine Centre, drug makers AstraZeneca and Pfizer and the University of Birmingham. It examines 28 genes in the DNA of the patient’s tumour, and uses the results to tailor treatment to “what makes that tumour tick”, according to Gary Middleton, professor of medical oncology at the University of Birmingham.

About 15%-20% of lung cancer tumours have a genetic abnormality that can be targeted, a proportion the Matrix trial hopes to expand.

“Lung cancer used to be a very simple disease,” says Middleton. “There were very few treatments and patients did very poorly. It’s really quite complicated now. Keeping on top of the new drugs and the new indications is difficult.” A specific drug may only be of use for one lung cancer patient in 100: “But for that one patient, it makes a huge difference.”

Diabetes is also benefiting from genomics. Researchers at the University of Exeter discovered the main cause of neonatal diabetes, a very rare condition that affects babies: half possess a genetic variant that prevents insulin being released from the pancreas. “If you give them a sulphonlylurea tablet, these patients can release insulin and stop insulin injections,” says Prof Sian Ellard, head of molecular genetics at the Royal Devon and Exeter NHS foundation trust, which is the university’s partner for its medical school.

The trust’s laboratory has provided free testing for more than 1,500 neonatal diabetes patients around the world. It also runs NHS tests for other kinds of diabetes, as well as a single test covering more than 5,000 rare genetic disorders.

This work has implications for staff. Royal Devon and Exeter is a training centre for a national programme to develop NHS bioinformaticians to process the vast amounts of data produced by genomic testing. Genetics specialists need to keep up with rapid developments in the field and understand the limitations of these new tests.

“There are gaps, and we need to remember that a genetic variant causing a disorder might be in one of those gaps,” says Ellard. “We never know quite what we’re missing. It’s critical to understand the limitations, as well as the enormous benefits.” There is also a need to simplify and standardise the reporting of genomic test results so they are understandable by all healthcare professionals and patients, she adds.

These new genomic tests will affect staff working in nearly all medical specialties and Health Education England (HEE) has developed a genomics education programme to run alongside the 100,000 Genomes Project run by Department of Health-owned company Genomics England. “The aim is to reach all healthcare professionals, be they doctors, nurses, allied healthcare professionals or laboratory staff and increase everybody’s general understanding of genomic medicine, what it is and how it can bring benefits to patients,” says Ellard.

Ten universities – including Exeter – offer a masters in genomic medicine, funded by HEE. The University of Exeter also supports education in monogenic diabetes through an annual international symposium, online education via a MOOC and hosts a national network of genetics diabetes nurses, trained in how to recognise patients likely to have monogenic diabetes, organise genetic testing, explain test results to patients, arrange testing for relatives and change treatments according to the test result.

Genetic tests can also help avoid adverse reactions to drugs, something that is helping to spread their use across the NHS. HIV drug Abacavir causes a serious reaction in about 5% of patients, but in 2004 researchers including Sir Munir Pirmohamed, NHS chair of pharmacogenetics at the University of Liverpool, published research on a genetic test that identified those at risk. The test was implemented across the NHS in 2006, and now less than 1% of patients suffer adverse reactions.

The university has developed a similar genetic test covering Warfarin – an anticoagulant used by about 1% of population – for use in GP surgeries. “Some people require half a milligram a day, some 20 milligrams a day,” says Pirmohamed. The NHS in the north-west of England is running a pilot through which nurses run this test on a patient’s blood to find the dose they need, with results in 45 minutes.

Pirmohamed believes genomics will combine with other ways to personalise medicine, including use of electronic patient records and data from patient-worn sensors.

“Genomics gives you a result,” he says. “What you need to do is implement those findings into the clinical care pathway, and that can be extremely complex. It requires someone to implement the information technology, an appropriate prescribing system as well as education and training of the prescribers, nurses and pharmacists who look after patients.”

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